About: gamma-secretase complex

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A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin

Attributes	Values
rdf:type	Item
description	Enzymfamilie (de) cellulaire component (nl) A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin (en) 複数のサブユニットからなるプロテアーゼ複合体、内在性膜タンパク質 (ja)
exact match	wds:Q15328541-4FABCB26-6B7A-49B6-B829-18B9798136EC wds:Q15328541-CB1A28D4-F9A4-4782-A8F9-DCB453EE9233
exact match	http://tcdb.org/search/result.php?tc=4.G.1 http://purl.obolibrary.org/obo/GO_0070765
rdfs:label	Gamma secretasa (ca) Gamma-Sekretase (de) gama-sekretáza (cs) gamma-secretase complex (en) Γ-セクレターゼ (ja) Γ分泌酶 (zh) غاما سيكريتاز (ar)
skos:prefLabel	Gamma secretasa (ca) Gamma-Sekretase (de) gama-sekretáza (cs) gamma-secretase complex (en) Γ-セクレターゼ (ja) Γ分泌酶 (zh) غاما سيكريتاز (ar)
name	Gamma secretasa (ca) Gamma-Sekretase (de) gama-sekretáza (cs) gamma-secretase complex (en) Γ-セクレターゼ (ja) Γ分泌酶 (zh) غاما سيكريتاز (ar)
has part(s) of the class	wds:Q15328541-14f93ee9-40bd-6b4e-4f43-3f8f4581f726 wds:Q15328541-22206d21-425c-6d3f-695a-9b00e4a51c5b wds:Q15328541-4b512e06-43d0-3e41-8158-46c84ae8adca wds:Q15328541-53c1c5f0-4381-2a4a-f051-c4eccea8b516
has part(s) of the class	Gamma-secretase subunit Aph-1 Peptidase A22A, presenilin 1 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit Nicastrin
Freebase ID	wds:Q15328541-65E425F3-561C-4FC2-9871-1697ECDDF971
Freebase ID	/m/026b7cn
Gene Ontology ID	wds:Q15328541-5A330D68-4F80-4AED-A918-E99385EBCC66
Gene Ontology ID	GO:0070765
instance of	wds:Q15328541-43F40F89-781C-4EF7-80C6-8AA26F698638 wds:Q15328541-588B0119-3D6E-494F-8FFA-AB5AB64B21A2 wds:Q15328541-981e11c1-4ed6-c0f8-5080-a955fe618e9f
instance of	cellular component group or class of transmembrane transport proteins family of protein complexes
subclass of	wds:Q15328541-56C84F7A-7D6F-4392-8E14-2F2A4FBC0CD8 wds:Q15328541-60B1FD57-70EF-4C1C-B926-A57B347FAD98 wds:Q15328541-88350A7E-11AC-4345-950E-699235D12E54 wds:Q15328541-B9D8D241-166A-4C57-ACEB-DCC4A480F580
subclass of	aspartate protease plasma membrane protein complex catalytic complex group translocator
molecular function	wds:Q15328541-BD2C2E3B-4237-458A-844C-AA9757F5EB63
Transporter Classification Database ID	wds:Q15328541-5FCA54FC-4459-4E11-AC2C-4FB499A3E094
molecular function	aspartic endopeptidase activity, intramembrane cleaving
Transporter Classification Database ID	4.G.1
Commons category	wds:Q15328541-ae5313e0-3ff2-4c15-8087-2a6be5a376ee
Commons category	Gamma secretase
skos:altLabel	APH-1 (de) GO:0070765 (en) Nicastrin (de) PEN-2 (de) TCDB:4.G.1 (en) gamma secretase (en) gamma-secretase (en) presenilin complex (en) γ secretase (en) γ-secretase (en) γ-セクレターゼ (ja)
OpenAlex ID	wds:Q15328541-39184C0A-7998-43A3-A17F-CDC7DF0145F6
Microsoft Academic ID	wds:Q15328541-4B7BE856-F668-420F-8536-382A8FCC31AB
Microsoft Academic ID	https://makg.org/entity/2778171954
OpenAlex ID	C2778171954
Microsoft Academic ID	2778171954
is owl:sameAs of	gamma-secretase complex
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q15328541 Gamma secretase https://de.wikipedia.org/wiki/Gamma-Sekretase https://ja.wikipedia.org/wiki/%CE%93-%E3%82%BB%E3%82%AF%E3%83%AC%E3%82%BF%E3%83%BC%E3%82%BC Category:Gamma secretase https://cs.wikipedia.org/wiki/Gama-sekret%C3%A1za https://ar.wikipedia.org/wiki/%D8%BA%D8%A7%D9%85%D8%A7_%D8%B3%D9%8A%D9%83%D8%B1%D9%8A%D8%AA%D8%A7%D8%B2 https://ca.wikipedia.org/wiki/Gamma_secretasa
is subclass of of	Gamma-secretase complex, Aph1b-Psen1 variant Gamma-secretase complex, Aph1b-Psen2 variant Gamma-secretase complex, APH1B-PSEN2 variant Gamma-secretase complex, Aph1a-Psen2 variant Gamma-secretase complex, Aph1a-Psen1 variant Gamma-secretase complex Gamma-secretase complex, APH1A-PSEN2 variant Gamma-secretase complex, APH1B-PSEN1 variant Gamma-secretase complex, APH1A-PSEN1 variant
is subclass of of	wds:Q107602956-D47CB7F1-8529-4C42-8168-7E305339F04C wds:Q107602959-6A6866C1-8304-43E0-B295-1C5F91A95A1D wds:Q107515510-FE209222-0D37-46CC-BCA2-53C20D02CB46 wds:Q107602958-B2783ED6-108C-4955-995C-0C7EF8F32153

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