About: Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

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About: Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies Goto Sponge Distinct Permalink

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scientific article published on 19 August 2010

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2010 (fr) наукова стаття, опублікована в серпні 2010 (uk) scientific article published on 19 August 2010 (en) artículu científicu espublizáu n'agostu de 2010 (ast)
publication date	wds:Q84774538-FFDEE0FE-BA48-4C21-A192-5059439F066B
publication date	2010-08-19 00:00:00Z (xsd:dateTime)
exact match	wds:Q84774538-AA2E4A13-3062-4728-B772-C4A1EA2B9BF9
exact match	https://scigraph.springernature.com/pub.10.1038/leu.2010.167
cites work	wds:Q84774538-25F1A4A8-2E0E-4540-9FAA-637D4B9F2D88 wds:Q84774538-5039F68C-26B7-4297-B254-F81FE35B0E83 wds:Q84774538-6282E34A-BDF7-4948-8133-EFC27663C908 wds:Q84774538-68B68D48-A299-4F7F-8146-14AE76A45A20 wds:Q84774538-6AFEAB54-DDDB-48E8-B79E-9626D7FAE0B7 wds:Q84774538-72F4B078-A0D1-4446-8BD3-88AA249DA424 wds:Q84774538-740EBB3A-2DBE-45D4-8B1B-7C4F2D2DBA5F wds:Q84774538-E75DBC7B-59D4-4DB8-9920-4874B6A74C8A
cites work	Mutation in TET2 in myeloid cancers Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies TP53 mutations in myeloid malignancies are either homozygous or hemizygous due to copy number-neutral loss of heterozygosity or deletion of 17p. UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation. Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. Whole genome scanning as a cytogenetic tool in hematologic malignancies
author name string	wds:Q84774538-178AB5B4-A46A-4060-A887-822737631380 wds:Q84774538-1FC96B48-2347-4988-88BA-D0A97A3D4255 wds:Q84774538-2A1B7B62-0A5C-440E-877E-DB82A1D25DB4 wds:Q84774538-34B60E3F-C4A7-463E-BAB5-FF49223FBAA5 wds:Q84774538-3CA45457-86C3-42BF-9FF4-DAD1BA9539C3 wds:Q84774538-48E014CE-1C19-4D95-BA00-067AE1A98A32 wds:Q84774538-55B2CDA8-224B-4113-AFDE-332C0CA5D3A2 wds:Q84774538-5FAE46AD-5092-4952-AB47-0CA7C36770AC wds:Q84774538-A65A4848-5EE7-4E02-85D6-5D58BF2215CE wds:Q84774538-A6B1E65F-F64D-424F-BA57-F35317BB2FBB wds:Q84774538-AB0DE01C-BFFB-4D0A-A547-6F66FC7D3C60 wds:Q84774538-BCB7DC34-D8E3-40A3-BF89-71641A6D9869 wds:Q84774538-DC90739A-84A1-495E-9C6A-250B5339520B
author name string	Z Hu Y Sugimoto M A Sekeres M A McDevitt H Makishima R V Tiu Y Saunthararajah A M Jankowska H Szpurka K Guinta A R Moliterno P Putnam M A Keddache
rdfs:label	Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (en) Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (nl)
skos:prefLabel	Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (en) Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (nl)
name	Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (en) Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (nl)
author	wds:Q84774538-295ba5d1-4146-9efc-87ba-77e4bfe6fba3 wds:Q84774538-F598EAF6-5BDA-4185-97A6-A52AE7451AFF
author	Alan F List Jaroslaw P. Maciejewski
title	wds:Q84774538-645C0545-B3D3-407C-B8AA-1B51D41A5304
title	Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies (en)
page(s)	wds:Q84774538-C40BCC66-DF77-4C2B-8764-46A6A4865D27
page(s)	1799-1804
instance of	wds:Q84774538-EBE15B6E-8E87-4250-AD46-7434821306B8
instance of	scholarly article
PubMed ID	wds:Q84774538-1DB30060-A88E-4888-A5E1-460B1A0F2514
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20724984
PubMed ID	20724984
published in	wds:Q84774538-20E693FF-CDEB-4448-A537-64D24A2526F4
published in	Leukemia
issue	wds:Q84774538-232EBA25-48E6-46C8-8E42-7DCABE64242C
volume	wds:Q84774538-D1902D26-4D9C-4975-BE88-C57DE344B0DB
issue	10
volume	24
DOI	wds:Q84774538-C8C96634-4463-4F11-BE79-0A17136281A9
DOI	http://dx.doi.org/10.1038/LEU.2010.167
DOI	10.1038/LEU.2010.167
Dimensions Publication ID	wds:Q84774538-900BCE82-7C7D-4FA6-A71B-091EA1AC1DC6
Dimensions Publication ID	1037627473
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q84774538
is cites work of	Mutations in EZH2 cause Weaver syndrome Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies. Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide. Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain Genomic diversity in myeloproliferative neoplasms: focus on myelofibrosis Emerging patterns of somatic mutations in cancer Therapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromes Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Driver mutations of cancer epigenomes. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia. Unraveling the molecular pathophysiology of myelodysplastic syndromes A complex Polycomb issue: the two faces of EZH2 in cancer

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