About: Brian R. Murphy

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American virologist and former co-chief of the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Disease

Attributes	Values
rdf:type	Item
owl:sameAs	Brian R. Murphy
description	American virologist and former co-chief of the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Disease (en)
rdfs:label	Brian R. Murphy (en) Brian R. Murphy (es) Brian R. Murphy (nl) Brian R. Murphy (sq) Brian R. Murphy (ast) ব্রায়ান আর মার্ফি (bn) ബ്രയാൻ ആർ. മർഫി (ml)
skos:prefLabel	Brian R. Murphy (en) Brian R. Murphy (es) Brian R. Murphy (nl) Brian R. Murphy (sq) Brian R. Murphy (ast) ব্রায়ান আর মার্ফি (bn) ബ്രയാൻ ആർ. മർഫി (ml)
name	Brian R. Murphy (en) Brian R. Murphy (es) Brian R. Murphy (nl) Brian R. Murphy (sq) Brian R. Murphy (ast) ব্রায়ান আর মার্ফি (bn) ബ്രയാൻ ആർ. മർഫി (ml)
given name	wds:Q65658906-63FCFBAB-D883-42A8-B066-152353FC928C
given name	Brian
image	wds:Q65658906-B4DF4F74-9449-4D19-8A34-BE7A7F11E116
instance of	wds:Q65658906-AF95F9D0-9878-4E38-821C-3DDD7BED175F
image
instance of	Homo sapiens
Google Knowledge Graph ID	wds:Q65658906-1F000C32-435D-4317-A3B0-CA45D29BF591
Google Knowledge Graph ID	http://g.co/kg/g/11fmh40f2q
Google Knowledge Graph ID	/g/11fmh40f2q
Nationale Thesaurus voor Auteursnamen ID	wds:Q65658906-c5f34a7c-b216-43d3-b402-ebe558c5b061
occupation	wds:Q65658906-19c63f8b-33c9-49c2-a88c-9dcd90d8e288
NUKAT ID	wds:Q65658906-F3BE8A1D-9F47-44E8-9431-9A704A197801
sex or gender	wds:Q65658906-3F7A0668-C76F-4865-AD2E-28EA18C40E25
ISNI	wds:Q65658906-2177EA23-ED85-4203-9524-3CD02BB4B864
VIAF ID	wds:Q65658906-97737F98-4865-4EE6-911D-F3C9F6EB8667
date of birth	wds:Q65658906-7554e3ae-6ec3-4164-a413-dc4ea9672c72
educated at	wds:Q65658906-53913893-782c-4ade-8290-298191cbd55d
family name	wds:Q65658906-B310873B-66FE-4DFD-87A5-C339FF78E3BA
WorldCat Identities ID (superseded)	wds:Q65658906-24DB62B1-B51A-48A1-9F75-36EBF0A5B723
Nationale Thesaurus voor Auteursnamen ID	http://data.bibliotheken.nl/id/thes/p07116667X
VIAF ID	http://viaf.org/viaf/282240514
Nationale Thesaurus voor Auteursnamen ID	07116667X
occupation	scientist
NUKAT ID	n2016137134
sex or gender	male
ISNI	0000000455847217
VIAF ID	282240514
date of birth	1942-01-01 00:00:00Z (xsd:dateTime)
educated at	Center for Advanced Studies
family name	Murphy
WorldCat Identities ID (superseded)	viaf-282240514
is about of	Brian R. Murphy https://www.wikidata.org/wiki/Special:EntityData/Q65658906 Brian R. Murphy https://ml.wikipedia.org/wiki/%E0%B4%AC%E0%B5%8D%E0%B4%B0%E0%B4%AF%E0%B4%BE%E0%B5%BB_%E0%B4%86%E0%B5%BC._%E0%B4%AE%E0%B5%BC%E0%B4%AB%E0%B4%BF
is author of	Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in mice Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys. Nonsegmented negative-strand viruses as vaccine vectors Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4. Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region. Attenuation of the recombinant human parainfluenza virus type 3 cp45 candidate vaccine virus is augmented by importation of the respiratory syncytial virus cpts530 L polymerase mutation An influenza A live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman Primates Development of a live attenuated dengue virus vaccine using reverse genetics Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeys Chimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity. Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys Temperature sensitive mutations in the genes encoding the NS1, NS2A, NS3, and NS5 nonstructural proteins of dengue virus type 4 restrict replication in the brains of mice Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cells Evaluation of three strains of influenza A virus in humans and in owl, cebus, and squirrel monkeys Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys. Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity. Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo Heterotypic dengue infection with live attenuated monotypic dengue virus vaccines: implications for vaccination of populations in areas where dengue is endemic Cold-Adapted Variants of Influenza A Virus: Evaluation in Adult Seronegative Volunteers of A/Scotland/840/74 and A/Victoria/3/75 Cold-Adapted Recombinants Derived from the Cold-Adapted A/Ann Arbor/6/60 Strain Evaluation of A/Alaska/6/77 (H3N2) cold-adapted recombinant viruses derived from A/Ann Arbor/6/60 cold-adapted donor virus in adult seronegative volunteers Temperature-sensitive mutants of influenza A virus. Transfer of the two ts-1A2 ts lesions present in the Udorn/72-ts-1A2 donor virus to the influenza A/Alaska/6/77 (H3N2) wild type virus Temperature-sensitive mutants of influenza A virus: evaluation of the Alaska/77-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers Cold-adapted variants of influenza virus A. I. Comparison of the genetic properties of ts mutants and five cold-adapted variants of influenza virus A Biological, genetic and biochemical characterization of a cold-adapted recombinant A/Victoria/3/75 virus and its evaluation in volunteers

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