About: P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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scientific article published on June 1996

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 1996 (ast) наукова стаття, опублікована в червні 1996 (uk) مقالة علمية نشرت في يونيو 1996 (ar) scientific article published on June 1996 (en)
publication date	wds:Q37355653-8CC1653D-89FE-4DED-815A-E8BD9AF9E76F
publication date	1996-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37355653-A7C69250-2CA9-4547-9080-A220EA64DA21
language of work or name	English
cites work	wds:Q37355653-1DECC576-961E-4FB6-A91B-1DA08DE9D881 wds:Q37355653-2DF14E3C-F439-4488-B870-6D3A8A6CBCE9 wds:Q37355653-429223B8-A961-41EF-A09C-93A0D5ACE064 wds:Q37355653-5331A5F0-E21F-4AE0-AE1C-0D5EBA59C395 wds:Q37355653-59DBFDE5-BE80-40AC-9A14-58143B59E597 wds:Q37355653-641A1E9A-EC5A-45DD-A3E3-25216D9D7DB3 wds:Q37355653-6F9089D1-94EC-4D59-916C-CADE5E33FB4D wds:Q37355653-75A7D401-9A8D-4BD5-861F-64B362546AFA wds:Q37355653-807592A7-C914-48E0-9526-7F4366750A9B wds:Q37355653-843FDB4E-408B-4D13-995C-54BE2C25EDB1 wds:Q37355653-86266B76-5FF1-4C60-8B98-2D334F6E48B2 wds:Q37355653-8B475430-FE75-4C54-8F40-FC6A40A4BF36 wds:Q37355653-8D6C3BD0-4541-4661-BCD7-E33736F24161 wds:Q37355653-90F9C7FB-B922-4B72-BAF7-3F310795206B wds:Q37355653-96B0DF81-21B9-4BC6-BB4B-E6D9271DABB0 wds:Q37355653-A895F982-BF63-4894-AA8C-187350D9AD91 wds:Q37355653-B16E9B22-062C-4192-9EA2-797CFDDE395E wds:Q37355653-B540E6F1-14C2-4454-AC44-BEA63F62BB01 wds:Q37355653-C1623ABF-72F5-4339-89C5-48C7020F5D42 wds:Q37355653-C5BFC88C-070E-44C0-A39D-CEC0DC02124E wds:Q37355653-CC745D0A-68F9-4052-980B-1F28F1F93AE9 wds:Q37355653-D6101A5A-6393-4A29-AB20-79FED6A12790 wds:Q37355653-DFD32E23-F2ED-4E93-A930-46D76837B45D wds:Q37355653-E9166BB1-1862-4CB6-BFFA-929405DB9D63 wds:Q37355653-F6F71777-9C50-4CCB-87A3-655722E015F9 wds:Q37355653-F710234F-680A-4607-BC18-B5953CEECDB6 wds:Q37355653-F8209973-AFD5-4747-8179-74C25C701BB8 wds:Q37355653-F88D9D79-E813-433E-93D1-F4305D898932 wds:Q37355653-FC291B6C-6C65-4159-A058-23E05D84F891 wds:Q37355653-FC9C001C-BAE4-4388-A047-9C2DABC99824
cites work	Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate Biochemistry of multidrug resistance mediated by the multidrug transporter Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16 MDR1 gene expression in brain of patients with medically intractable epilepsy Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites The biochemistry of P-glycoprotein-mediated multidrug resistance Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833 A method to determine the ability of drugs to diffuse through the blood-brain barrier On the pharmacokinetics of domperidone in animals and man. I. Plasma levels of domperidone in rats and dogs. Age related absorption and passage through the blood brain barrier in rats Modulation of multidrug resistance: at the threshold Review of the preclinical pharmacology and comparative efficacy of 5-hydroxytryptamine-3 receptor antagonists for chemotherapy-induced emesis Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity
author name string	wds:Q37355653-6F82F1E4-07B5-433B-B65E-61DBF2319CF4 wds:Q37355653-85CFF05C-03EA-44EF-9108-1E6F5DEA84C6 wds:Q37355653-CB122B7D-521F-45BC-BE55-5B227B635180 wds:Q37355653-FD05F2FF-6209-4ED8-A077-36D2D0340376
author name string	Schinkel AH Mol CA Wagenaar E van Deemter L
rdfs:label	P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (en) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (nl) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (ast)
skos:prefLabel	P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (en) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (nl) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (ast)
name	P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (en) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (nl) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (ast)
title	wds:Q37355653-C2D2CB5C-F26B-4B52-B803-BE83D499C5B1
title	P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs (en)

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