About: BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

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scientific article published on 17 March 2008

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rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2008 (ast) наукова стаття, опублікована в березні 2008 (uk) مقالة علمية نشرت في 17 مارس 2008 (ar) scientific article published on 17 March 2008 (en)
publication date	wds:Q37297138-446A9F3E-5DEC-44CB-A202-DCDF6239C2BE
publication date	2008-03-17 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37297138-567E2957-3CD5-44B2-BAC8-69BE8CD56423
language of work or name	English
cites work	wds:Q37297138-0A9C431D-1873-4535-9E77-D94A6382E23D wds:Q37297138-0FFA913E-600A-4AA4-8375-294F06C2C6E1 wds:Q37297138-13F40E24-7130-4094-86FA-CBAD83A19403 wds:Q37297138-15CCD59E-3C0B-43B9-85A8-9B87C6673566 wds:Q37297138-212790D3-CC39-4DD9-822C-B270232A4F9B wds:Q37297138-2D601B11-E428-487C-AC1B-3BB415698E7A wds:Q37297138-31296D11-E413-4815-9F8E-50E3619B83FB wds:Q37297138-3569658B-16E1-415B-8E0D-13DB8EBD213E wds:Q37297138-36864AE0-9D63-43B1-9542-88B156BD7125 wds:Q37297138-3C4E28BE-CBA4-445B-82F9-FDA961821A13 wds:Q37297138-3EB6BAD8-52F4-4845-837F-AB3BB7EF1B6F wds:Q37297138-4D948B26-C39A-4F93-9EFB-B6FFA531BF19 wds:Q37297138-5C35309F-EFCC-4294-98C4-1006E753B88D wds:Q37297138-5E2F1ED6-CCCF-412C-A260-5493CD0C52EC wds:Q37297138-630F1395-C9F8-46F6-A362-3B242BBD59F9 wds:Q37297138-631DA287-95B9-4DC2-8606-27B8151B2CF6 wds:Q37297138-6C4E28D6-E83D-4088-8556-649BCA1CBC8F wds:Q37297138-703B000D-C2DC-4F42-9AAF-76A29D168D70 wds:Q37297138-7104CCDA-2290-4941-B226-EB906A1D62C2 wds:Q37297138-7A6C30CA-8733-4977-AC1E-03044B0F113B wds:Q37297138-8F02A966-E175-4287-90DD-0F2A3A8E9DFC wds:Q37297138-AE6F82E3-1FF0-4EEF-9594-1AEBF6D21FB1 wds:Q37297138-BD180FBA-46E7-47D0-BC6F-DF47F9694B92 wds:Q37297138-C23C988D-2693-4BD8-B04D-E6D2E9CD6EC4 wds:Q37297138-CEE99C2D-B536-4E5C-A9BF-B146B2613D6A wds:Q37297138-DB8B64F7-7E91-4343-BDD5-E7EA80C3BBFE wds:Q37297138-E70ADAEB-1B34-4762-AE9E-D697D632CD56 wds:Q37297138-E81F7926-5BFD-4F50-A784-5FA33D3EA4D4 wds:Q37297138-F660C0DC-BC7D-41D5-8546-0D9C3DEA8222 wds:Q37297138-F8D4901A-D9FB-4FCF-A255-4C83CC0E647B wds:Q37297138-F90F4D96-7C38-4C9E-92DD-8B226E8EE48D wds:Q37297138-FDD3C39C-FF34-4D9D-8CED-5C73A31A615A wds:Q37297138-FF07ABD1-DD53-4F9D-8C43-545CAD1DAA59
cites work	A role for ATR in the DNA damage-induced phosphorylation of p53 WAF1, a potential mediator of p53 tumor suppression Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain The ATR pathway: fine-tuning the fork BCL6 encodes a sequence-specific DNA-binding protein DNA damage checkpoints in mammals Chk1 is haploinsufficient for multiple functions critical to tumor suppression The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. The human BCL6 transgene promotes the development of lymphomas in the mouse Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma Control of inflammation, cytokine expression, and germinal center formation by BCL-6 BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation Germinal centers Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms Transcriptional analysis of the B cell germinal center reaction BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells BCL-6 expression during B-cell activation. Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Activation-induced deaminase: light and dark sides Chk1 versus Cdc25: chking one's levels of cellular proliferation
author name string	wds:Q37297138-05BA2024-D6EF-40F5-BE48-92BEBC218B0B wds:Q37297138-124ADE14-8F69-4E6A-B2D6-7E2CA71E12E5 wds:Q37297138-CDA85386-3586-4194-900F-00C60A6C558B
author name string	Ari Melnick Jose M Polo Stella M Ranuncolo
rdfs:label	BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells (en) BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells (ast) BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. (nl)
skos:prefLabel	BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells (en) BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells (ast) BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. (nl)
name	BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells (en)

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