About: Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction

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About: Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction Goto Sponge Distinct Permalink

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scientific article published on 03 January 2008

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rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2008 (ast) наукова стаття, опублікована в січні 2008 (uk) scientific article published on 03 January 2008 (en) مقالة علمية نشرت في 03 يناير 2008 (ar)
publication date	wds:Q37156730-E6B18830-5E97-4B0B-827B-E7FEB8A93292
publication date	2008-01-03 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37156730-F019D7FE-933A-4310-B2E7-F03E90F707CB
language of work or name	English
cites work	wds:Q37156730-039AD696-5535-4F53-9974-FD1EB58771A9 wds:Q37156730-146F7E6B-3746-40A4-8CD4-9A5355C32E89 wds:Q37156730-26F69B85-214F-434A-9885-EB1104B9C19D wds:Q37156730-311F812A-4FBA-4B2D-9BA9-978FF2609505 wds:Q37156730-3576FD5F-F545-42AF-9FE0-333FD8EC982A wds:Q37156730-390CB382-1023-4299-86FF-E87FAACB0E18 wds:Q37156730-3F22EACB-9DA4-4968-9931-D2D056EA923E wds:Q37156730-4BF1C796-4E37-4DE4-A289-80EB48729136 wds:Q37156730-51ABB17E-A096-43F1-A357-7C8F2E4B1C7A wds:Q37156730-62D2E782-6DED-440E-8D60-015C4F3A4882 wds:Q37156730-65CA1DEC-D484-4A64-B1A3-321B73A22FDC wds:Q37156730-691948C3-8EDD-4E2E-96A5-8D67FB273CF0 wds:Q37156730-6C5818AC-91F2-4AE5-BC7E-CC3CF83E612B wds:Q37156730-6F6B9C28-6CAB-4C4B-9BF8-BB1EE4975594 wds:Q37156730-70507173-0D89-4DE0-AB3B-778AF1C2F451 wds:Q37156730-706FAE48-A861-471B-AD61-F11F03749EC0 wds:Q37156730-7AC45C74-D3D3-4545-836D-9A9D0B61EA2D wds:Q37156730-8BB52F00-8679-43C8-B672-7B1C84CE4AB2 wds:Q37156730-8F22D3CE-5BFE-45AB-8046-C42F2EF9EB66 wds:Q37156730-921B9978-6584-4D4C-8763-621AF111546E wds:Q37156730-96BA525A-B1B7-4837-BA64-96B03C1401F2 wds:Q37156730-9B55FEC3-587C-495C-B139-8248E2B787C7 wds:Q37156730-A24834E3-38E9-44EC-A056-3AE2C1F1F627 wds:Q37156730-ABF6E5C1-96F4-492E-B174-9BA00BF1C813 wds:Q37156730-B412612E-6F7D-427B-B692-E148BF7C23C1 wds:Q37156730-B5511EBC-CEEC-4272-9D0C-AABB466C7F21 wds:Q37156730-B7D678E9-45E7-443B-A8A5-EA92A8EAFE08 wds:Q37156730-BE3AF533-CF71-43C4-B43E-FAA4CA6F19FA wds:Q37156730-BFB35201-DC4B-4DFD-9B85-F0E87E6ACD50 wds:Q37156730-C334F981-085B-45B4-8861-D4631486A7C9 wds:Q37156730-D3C5D311-EB61-4F69-9D84-DD4B130AFAAB wds:Q37156730-D6D8606E-23D4-4649-BDC8-39BD67A52233 wds:Q37156730-ED4446D5-8B88-42B9-A7A4-674455E3E8CA wds:Q37156730-F712C800-3477-4851-8504-A094F8C388F7 wds:Q37156730-F837B0C3-57F4-41A6-BC7D-4DA6CAEE4DE6
cites work	Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene Targeted disruption of the melanocortin-4 receptor results in obesity in mice Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Structure of a cannabinoid receptor and functional expression of the cloned cDNA Molecular characterization of a peripheral receptor for cannabinoids International Union of Pharmacology. XXVII. Classification of cannabinoid receptors The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects Cannabinoid receptor agonist efficacy for stimulating [35S]GTPgammaS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity. Cysteine residues in the human cannabinoid receptor: only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding The orphan receptor GPR55 is a novel cannabinoid receptor A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor Allosteric modulation of the cannabinoid CB1 receptor Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor Inverse agonist activity at the alpha(2A)-adrenergic receptor. Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation The MC4 receptor and control of appetite The proximal and distal C-terminal tail domains of the CB1 cannabinoid receptor mediate G protein coupling Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling Regulation of thermogenesis by the central melanocortin system An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas. A mutation in the second transmembrane region of the CB1 receptor selectively disrupts G protein signaling and prevents receptor internalization. The endocannabinoid system: a new target for the regulation of energy balance and metabolism
author name string	wds:Q37156730-1E56FF08-E7FF-4E6D-9444-09DD972D04D1 wds:Q37156730-2EFE7F21-F6D2-4392-A3C1-C6E6F0C188A9 wds:Q37156730-311D8E77-030D-4F67-BE28-715B96C283CE wds:Q37156730-DB1CB850-48D7-42C8-B89E-5789E973D7BC
author name string	Ganesh A Thakur Ankur Kapur Mary E Abood Patrick Samaniego
rdfs:label	Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction. (nl)

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