About: A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

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About: A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory Goto Sponge Distinct Permalink

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scientific journal article

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description	artículu científicu espublizáu en 1997 (ast) vědecký článek publikovaný v roce 1997 (cs) 1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած (hyw) 1997 թվականի նոյեմբերին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована в листопаді 1997 (uk) vedecký článok (publikovaný 1997/11/21) (sk) wetenschappelijk artikel (gepubliceerd op 1997/11/21) (nl) مقالة علمية (نشرت في 21-11-1997) (ar) article publié dans la revue scientifique Journal of Biological Chemistry (fr) scientific journal article (en) im November 1997 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28645870-A3A55EB0-5E3F-491E-A3A1-959A9F49EFA9
publication date	1997-11-21 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28645870-69AC506C-05C9-41F9-A1F9-3913701F198E
language of work or name	English
cites work	wds:Q28645870-11883C5D-851E-4E85-BA4E-DDEB5B96A29C wds:Q28645870-15F2C16B-004B-4771-A8C0-FF3E839DA0B0 wds:Q28645870-1FC44FFF-3E5B-46D4-AC42-07AF44F97EA5 wds:Q28645870-368BD2B4-EBCE-48C9-AF45-AD2A73D998AC wds:Q28645870-376D4960-6C46-4CBE-86E6-AE8A49F97D15 wds:Q28645870-3C67EB8A-2A98-45D7-9C6B-29BD72CE002D wds:Q28645870-437AB17D-CBA1-457A-946D-312B9FEA74C8 wds:Q28645870-50B2AE14-C33C-4245-9755-B414AA24C86E wds:Q28645870-52BCCF75-7F38-4C37-A374-38793CC5DA8E wds:Q28645870-5F16A21E-D3A5-42B4-A22C-BBC8646AE655 wds:Q28645870-61885E53-5E46-48FE-BB72-80ECABA25785 wds:Q28645870-632C6554-AB18-4274-815B-D35A123BF1D4 wds:Q28645870-7BACFDD0-0720-4C42-BE23-CFAE6306B230 wds:Q28645870-8099B024-677A-4073-86BB-CD8414B20E6D wds:Q28645870-81E6FD75-A3E4-4726-8020-EEB86D178DB0 wds:Q28645870-8E4D2E8C-C9C7-4650-9758-1A65E5EB5FBF wds:Q28645870-95A40C13-2038-4CE2-AC3F-232BE1366E0E wds:Q28645870-9729B52E-8DE3-40C2-A4B6-F1A9AA15AFD4 wds:Q28645870-9E50990E-84C1-4AF4-940F-FA287F1CF1CB wds:Q28645870-9EBA8E37-C196-4BC9-AA38-E2C3F6B270C4 wds:Q28645870-A5452CD2-B5FE-4372-919E-075A1E917726 wds:Q28645870-AB5FAB17-03C9-46D7-A85A-0D1EDF5B135F wds:Q28645870-B63FD7CB-A23A-4432-8CC5-0BEAF22945F2 wds:Q28645870-BBEBF2F2-23B6-4E93-8E57-85F47E5A1643 wds:Q28645870-C2B52004-6277-4D0E-83B2-3F776D9B37A4 wds:Q28645870-D58F39F2-3DB3-4EA8-9B19-E317372CE0CD wds:Q28645870-DECE8B0D-7265-4995-8B35-4707F72167D8 wds:Q28645870-E4310263-1682-470F-951A-7A9AA0EB37AB wds:Q28645870-E6CF11D3-548E-472A-BF95-5D3FA539F781 wds:Q28645870-FAD55667-FD4F-40D7-81FB-E9775CCF4DF6 wds:Q28645870-FB2CFBB5-686E-4F02-872D-5697821B628B
cites work	Role of IRS-2 in insulin and cytokine signalling Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. Tumor necrosis factor alpha inhibits signaling from the insulin receptor General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786 Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways Two tumour necrosis factor receptors: structure and function. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death Adipogenesis and obesity: rounding out the big picture Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism Galectin-8. A new rat lectin, related to galectin-4 The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action The adipocyte: storage depot or node on the energy information superhighway? Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase Biochemical mechanisms of insulin resistance Inhibition of insulin receptor signaling by TNF: potential role in obesity and non-insulin-dependent diabetes mellitus The insulin receptor: structure and function PITC derivatives in amino acid analysis Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells
author name string	wds:Q28645870-9081D580-A52E-4148-9EA1-B73CBE71214F wds:Q28645870-A1AB81A0-E4DD-4A31-B7AB-D94E6C59201A wds:Q28645870-A73E2F98-F453-47CC-AE45-A01CA2FCA949 wds:Q28645870-A8567F8F-AD74-4100-9254-70299D87932E wds:Q28645870-A9BB5732-5CDA-47A6-B82A-736C02E64352 wds:Q28645870-B1248887-119E-4C31-BD2E-9197CEA63FE0 wds:Q28645870-C70F78C0-071C-4AB6-AC36-F631A4E4C14C
OpenCitations bibliographic resource ID	wds:Q28645870-7AAE52A3-E947-4E7F-9897-EAA34F6732BE
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/2809497
author name string	D. LeRoith Y. Zick R. Hemi A. Karasik E. Elhanany H. Kanety K. Paz
OpenCitations bibliographic resource ID	2809497
rdfs:label	A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory (en) A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory (nl) A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory (ast)
skos:prefLabel	A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory (en) A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory (nl)

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