About: PTIP promotes chromatin changes critical for immunoglobulin class switch recombination

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description	artículu científicu espublizáu en 2010 (ast) vědecký článek publikovaný v roce 2010 (cs) наукова стаття, опублікована в серпні 2010 (uk) 2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած (hyw) 2010 թվականի օգոստոսին հրատարակված գիտական հոդված (hy) wetenschappelijk artikel (gepubliceerd op 2010/08/20) (nl) vedecký článok (publikovaný 2010/08/20) (sk) مقالة علمية (نشرت في 20-8-2010) (ar) article publié dans la revue scientifique Science (fr) scientific journal article (en) im August 2010 veröffentlichter wissenschaftlicher Artikel (de) 2010 ആഗസ്റ്റ് 20 നു പ്രസിദ്ധീകരിച്ച ശാസ്ത്ര ലേഖനം (ml)
publication date	wds:Q28585503-988E0D7B-4D21-4CD2-9AB1-739F5C9FA8E5
publication date	2010-08-20 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28585503-586E4AA8-0588-4CEC-9537-AE06C5259DBF
language of work or name	English
cites work	wds:Q28585503-00110E94-5868-47A5-AD27-19A578FDEB78 wds:Q28585503-059B27D3-5F30-4875-AC3F-C68BEC15B199 wds:Q28585503-073ADD0E-4515-48AF-8448-242668C4A7D5 wds:Q28585503-09D962DC-A001-43CE-AF11-99C79BA0BD0E wds:Q28585503-0C7F35AD-A230-4480-8392-7257CB9DEE76 wds:Q28585503-15FD40AB-C339-4A2F-A16F-C20E62585838 wds:Q28585503-1661AB2C-49F6-4781-A88B-C4B4080A3E1B wds:Q28585503-1F4CDE84-A026-4630-ADB1-680132050BD3 wds:Q28585503-25E9BCDD-628E-4E41-98D1-CC0CF591B3F1 wds:Q28585503-2706F20B-E366-4FB2-90D6-7607ADB663A7 wds:Q28585503-2FE885B8-5217-4032-BECF-EBFD07A1A91E wds:Q28585503-33EA7BF0-B6F6-4F09-931B-7BF1DF3ACDD8 wds:Q28585503-3564DDB5-C702-42FE-B081-270DBF0237C4 wds:Q28585503-3DDBD651-E36B-4201-9580-92DEE63CCA4A wds:Q28585503-44A77C07-5703-478F-B3C3-F889EBC28AB0 wds:Q28585503-4507F552-BC4E-465C-8068-B6802C5B02C9 wds:Q28585503-4D54BF56-20EE-4333-B598-4F2421620553 wds:Q28585503-5BE41741-E951-4912-8BDE-10256B6BB377 wds:Q28585503-5DE8CF93-1945-4803-94CF-4DEA83BD0B05 wds:Q28585503-7AC6080E-D7E4-47EF-A12C-D6FED28BD58D wds:Q28585503-7F3EB4F0-EC27-4A19-946A-713F89A7A983 wds:Q28585503-836EB052-9413-4306-8535-84C30EC390DD wds:Q28585503-9F64CFD8-38FB-4DEA-AFB7-8738C8BC15CC wds:Q28585503-C18D9338-F1C4-436D-A7AE-EB5773376B6F wds:Q28585503-C83A9251-1FE5-42BD-8D91-D6C1DACB4D6F wds:Q28585503-CBA9C997-676C-446B-BD42-D42AC674717F wds:Q28585503-CC6E9526-2C92-419B-BE38-22E2F2F87E4F wds:Q28585503-CD162362-AF55-4A60-A33D-74AF07A9A3ED wds:Q28585503-CDB2C555-8EEE-4DD2-926C-23DACD9A3561 wds:Q28585503-CF56B3FE-10D5-47C0-A1FD-F4DC6260D3C8 wds:Q28585503-D421BF6B-2391-49AC-8A9A-4E528367CF5C wds:Q28585503-D74D98BB-307F-4A19-816F-4D4C48F38BA1 wds:Q28585503-DE0B72FC-0CC4-456D-93F4-6FCEBEFEFB4C wds:Q28585503-DEB03270-2C16-4A53-AC1E-C0AC54543FAE wds:Q28585503-EEC477D8-99E9-4130-93E1-18E3DB02201E wds:Q28585503-EFBB7F54-1CDE-4506-B7CF-E79E0FB07C20 wds:Q28585503-F018028A-66F5-4003-866F-4C86C45B59ED wds:Q28585503-F65A3715-88A0-4E99-AFD2-780B8E4B4B80 wds:Q28585503-FFA9FE43-DE8F-41DF-81AE-C6C3171D48F7
cites work	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth ATM prevents the persistence and propagation of chromosome breaks in lymphocytes H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. The role of chromatin during transcription A chromatin landmark and transcription initiation at most promoters in human cells Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage PTIP promotes DNA double-strand break repair through homologous recombination The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination Transcription-targeted DNA deamination by the AID antibody diversification enzyme Origin of chromosomal translocations in lymphoid cancer Mechanism and regulation of class switch recombination Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression The genomic landscape of histone modifications in human T cells BRCT domain-containing protein PTIP is essential for progression through mitosis Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8 Neoplastic development in plasma cells Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways PTIP regulates 53BP1 and SMC1 at the DNA damage sites Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice Transcription-coupled events associating with immunoglobulin switch region chromatin Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark Characterization of human epigenomes
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