About: Vijay Chudasama

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British organic chemist

Attributes	Values
rdf:type	Item
description	연구원 (ko) araştırmacı (tr) wetenschapper (nl) дослідник (uk) эрдэмтэн (mn) 研究者 (zh) հետազոտող (hy) British organic chemist (en)
rdfs:label	Vijay Chudasama (en) Vijay Chudasama (es) Vijay Chudasama (nl) Vijay Chudasama (ast)
skos:prefLabel	Vijay Chudasama (en) Vijay Chudasama (es) Vijay Chudasama (nl) Vijay Chudasama (ast)
name	Vijay Chudasama (en) Vijay Chudasama (es) Vijay Chudasama (nl) Vijay Chudasama (ast)
LinkedIn personal profile ID	wds:Q64313985-49337a3b-4bd6-8ad9-1cf1-160ff566f21f
LinkedIn personal profile ID	vijay-chudasama-0a588476
given name	wds:Q64313985-5183eefc-4210-6615-2d6c-92f54c4da0b7
given name	Vijay
instance of	wds:Q64313985-FAAAA5E1-8F5C-46E1-9682-75BB8B0622BC
instance of	Homo sapiens
award received	wds:Q64313985-cbfec6dc-43cb-e94e-5f55-f6babd64be65
award received	Hickinbottom Award
Google Scholar author ID	wds:Q64313985-7cf8e5ce-418e-fe18-6fdf-5b45e10fdaec
Google Scholar author ID	H4vUp7IAAAAJ
occupation	wds:Q64313985-BC3C6F84-7BCB-4879-A73A-F788F000699E wds:Q64313985-b6ecabcb-476e-72ca-ff84-a49200246934
employer	wds:Q64313985-e18caeb2-41f1-5be2-4e11-9b54092c3c72
sex or gender	wds:Q64313985-745fed03-470e-f302-e2c7-1717692c27e8
country of citizenship	wds:Q64313985-91c68762-49bd-b311-048b-1aa9cd3025af
educated at	wds:Q64313985-0000f1e9-4952-52ea-1a43-521168628e78
family name	wds:Q64313985-66cf9133-4028-ee15-92a9-2b1706db423d
occupation	researcher organic chemist
employer	University College London
sex or gender	male
country of citizenship	United Kingdom
educated at	University College London
family name	Chudasama
ORCID iD	wds:Q64313985-2F4FCB9B-6E2F-4B07-9F26-70EF0EE64B23
ORCID iD	https://orcid.org/0000-0002-8876-3285
ORCID iD	0000-0002-8876-3285
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q64313985
is author of	Optical control of trimeric P2X receptors and acid-sensing ion channels A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC) Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates. Recent advances in the construction of antibody-drug conjugates Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment Bromomaleimide-linked bioconjugates are cleavable in mammalian cells A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine. A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates. Advances in targeting the folate receptor in the treatment/imaging of cancers. Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification. Dual modification of biomolecules. Next-generation disulfide stapling: reduction and functional re-bridging all in one. A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. Motional timescale predictions by molecular dynamics simulations: case study using proline and hydroxyproline sidechain dynamics. Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation. Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis. Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability Antibody fragments as nanoparticle targeting ligands: a step in the right direction Forming next-generation antibody-nanoparticle conjugates through the oriented installation of non-engineered antibody fragments. Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range. Fine-tuning thio-pyridazinediones as SMDC scaffolds (with intracellular thiol release via a novel self-immolative linker) A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water Minireview: Addressing the retro-Michael instability of maleimide bioconjugates Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones. Functionalised thermally induced phase separation (TIPS) microparticles enabled for "click" chemistry Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance Aerobically-initiated C(sp3)-H bond amination through the use of activated azodicarboxylates Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering A rapid, site-selective and efficient route to the dual modification of DARPins. Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water Metal-free, hydroacylation of C=C and N=N bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions Homogeneous antibody-drug conjugates via site-selective disulfide bridging Assembly of High-Potency Photosensitizer-Antibody Conjugates through Application of Dendron Multiplier Technology. Synthesis of a novel HER2 targeted aza-BODIPY-antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation. Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones. Cysteine-to-lysine transfer antibody fragment conjugation Recent advances in metal-free aerobic C-H activation Tyrosine bioconjugation - an emergent alternative A versatile synthesis of 2,4-substituted oxazoles. Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines E- and Z-stereoselectivity in the preparation of enamides from glycidyl sulfonamides and carbamates Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation

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